The Morton Lab

RNA Biology, Molecular Neuroscience, Drosophila,
Human Stem Cells, Human Brain Organoids

Find out more about our research at USC

The primary research goal of the Morton lab is to study the fundamental mechanisms of post-transcriptional regulation of gene expression with an emphasis on RNA processing factors mutated in complex brain disorders.

Derrick J. Morton, PhD

Assistant Professor
Molecular and Computational Biology
Department of Biological Sciences
University of Southern California

Dr. Morton received his PhD from Clark Atlanta University and completed his postdoctoral training at Emory University in Atlanta, Georgia

My research program focuses on how defects in a conserved and ubiquitous RNA-regulatory complex, the RNA exosome, contribute to neurological disease. To gain a comprehensive mechanistic understanding of these challenging biological questions, we emphasize taking a multidisciplinary approach. 

We employ molecular and transcriptomic approaches in Drosophila and human stem cell-derived neuronal cultures to understand the different aspects of post-transcriptional regulation of RNA in the nervous system.

Publications

    1. Jalloh B, Lancaster CL, Rounds JC, Brown BE, Leung SW, Banerjee A, Morton DJ, Bienkowski RS, Fasken MB, Kremsky IJ, Tegowski M, Meyer K, Corbett A, Moberg K. The Drosophila Nab2 RNA binding protein inhibits m6A methylation and male-specific splicing of Sex lethal transcript in female neuronal tissue. Elife. 2023 Jul 17;12:e64904. doi: 10.7554/eLife.64904. PMID: 37458420; PMCID: PMC10351920.

Morton Lab Members

Emily Arnold

PhD Student

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Nina Barr

PhD Candidate

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Nick Bitar

Research Technician

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Jash Gada

Undergraduate Student

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Lauryn Higginson

PhD Candidate

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Rylee Kang

Undergraduate Student

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Marisol Castellanos

PhD Candidate

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Maggie Torstrick

Undergraduate Student

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Xingjun Wang, PhD

Researcher

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Derrick Morton, PhD

Primary Investigator